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Updated: Feb 11, 2026

Murine Model of Wound Healing
Published on: May 28, 2013
[WOUND HEALING PROPERTIES OF THE RECOMBINANT HUMAN ANGIOGENIN IN THE GEL MEDICINAL FORM USED AS A TREATMENT IN THE
Zh Bokebayev1, I Kukiyev2, Z Shulgau2
1JSC "Astana Medical University", Astana; RSE "National Center for Biotechnology" under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan. Astana, Kazakhstan; «Tokuda Hospital Sofia», Republic of Bulgaria.
Abstract:
The aim of the study was to evaluate the wound healing properties of the recombinant human angiogenin drug in the gel form on the models of planar musculocutaneous wound and a linear wound. The rats were divided into 3 groups: 1st group - control animals, that did not get any treatment of wounds; 2nd group - experimental, where animals' wound surface was treated with recombinant human angiogenin in a gel medicinal form; and the 3rd group - a comparison group, where animals were treated with "Solcoseryl" drug. The resulted morphology data and the time of complete epithelialization of planar wounds suggest that the human angiogenin drug in gel form has a pronounced wound healing activity. The latter surpasses the studied parameters of the reference drug "Solcoseryl", by contributing to the acceleration of healing process of planar musculocutaneous and linear wounds in rats.
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