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Morphometric Evaluation of the Frontal Migraine Trigger Site
Jessica J Hsu1,2, Ashley M Stasiak1,2, Kavitha Ranganathan1,2
1Ann Arbor, Mich.; Los Angeles, Calif.; and Columbus, Ohio.
Plastic and Reconstructive Surgery
|April 27, 2018
Summary
Corrugator muscle size does not differ between migraine and control patients, suggesting muscle hypertrophy is not a primary cause of migraine headaches. Other factors like muscle hyperactivity may be more involved.
Area of Science:
- Neurology
- Anatomy
- Medical Imaging
Background:
- Migraine headaches are linked to peripheral nerve trigger sites in the craniofacial region.
- Hypertrophy of corrugator muscles is a hypothesized cause of migraine by compressing supraorbital and supratrochlear nerves.
Purpose of the Study:
- To investigate if corrugator muscle anatomy differs between individuals with and without migraine headaches.
- To determine the role of corrugator muscle size in migraine pathophysiology.
Main Methods:
- Retrospective review of computed tomographic scans from 63 migraine patients and 63 controls.
- Blinded, randomized morphometric evaluation of corrugator supercilii muscle volume and thickness using 3D image processing.
- Subgroup analyses for frontal and unilateral frontal migraine.
Main Results:
- No statistically significant difference in mean corrugator muscle volume or thickness between migraine and control groups.
- Mean corrugator volume: 1.01 cm³ (migraine) vs. 1.06 cm³ (control).
- Mean maximum thickness: 5.36 mm (migraine) vs. 5.50 mm (control).
Conclusions:
- Corrugator muscle hypertrophy is unlikely to be a major trigger for migraine headaches.
- Muscle hyperactivity or peripheral nerve sensitization are more probable causative factors in migraine development.
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