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The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible
M F Carlier1, D Pantaloni, J A Evans
1Laboratoire d'Enzymologie, CNRS, Gif-sur-Yvette, France.
FEBS Letters
|August 1, 1988
Abstract:
The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.