Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What are Viruses?00:50

What are Viruses?

128.4K
Overview
128.4K
Autophagy01:27

Autophagy

5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.9K
Predator-Prey Interactions02:39

Predator-Prey Interactions

21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.1K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.1K
Introduction to Virus01:28

Introduction to Virus

1.8K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.8K
Viruses of Archaea01:29

Viruses of Archaea

525
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
525

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In Vitro</i> and <i>Ex Vivo</i> evidence that pharmacological induction of the hypoxia response pathway efficiently restricts measles and Nipah virus infections.

Emerging microbes & infections·2025
Same author

Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis.

International journal of molecular sciences·2025
Same author

Deep Characterisation of Circulating Torque Teno Virus DNA Load in Crohn's Disease Patients.

Journal of medical virology·2025
Same author

Autophagy machinery as exploited by viruses.

Autophagy reports·2025
Same author

[Autophagy, dendritic cells, and Crohn's disease - "There is no point in running ; we must leave at the right time"].

Medecine sciences : M/S·2025
Same author

Human Endogenous Retroviruses Expression in Autoimmunity.

The Yale journal of biology and medicine·2024

Related Experiment Video

Updated: Feb 11, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K

Autophagy during Early Virus-Host Cell Interactions.

Christophe Viret1, Aurore Rozières1, Mathias Faure1

  • 1CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; INSERM, U1111, Lyon, France; CNRS, UMR5308, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, 21 Av T. Garnier, 69007 Lyon, France; Equipe labélisée FRM, Fondation pour la Recherche Médicale, Paris, France.

Journal of Molecular Biology
|April 27, 2018
PubMed
Summary

Autophagy, a cellular process, defends against viruses by degrading them. However, viruses have evolved strategies to evade or exploit autophagy for their own replication, impacting cell fate.

Keywords:
autophagyentryvirus

More Related Videos

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
09:57

Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster

Published on: March 14, 2019

11.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.4K
Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
09:57

Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster

Published on: March 14, 2019

11.4K

Area of Science:

  • Cellular Biology
  • Virology
  • Immunology

Background:

  • Autophagy is a fundamental cellular mechanism for degrading intracellular components and maintaining homeostasis.
  • It serves as a crucial cell-intrinsic defense against viral infections.
  • Viruses have developed complex strategies to counteract or manipulate autophagy.

Purpose of the Study:

  • To review the early-stage interactions between viruses and host cells involving autophagy.
  • To elucidate the consequences of these interactions on viral replication and cellular fate.
  • To summarize current knowledge on the interplay between autophagy and early viral invasion.

Main Methods:

  • Literature review of autophagy and virology research.
  • Analysis of studies focusing on early viral-host interactions.
  • Synthesis of findings on viral evasion and manipulation of autophagy.

Main Results:

  • Autophagy can target viral particles and components for degradation.
  • It can activate innate and adaptive immune responses against viruses.
  • Viruses actively subvert autophagy to promote replication and survival.

Conclusions:

  • The early interaction between autophagy and viruses is a dynamic interplay with significant implications for infection outcomes.
  • Understanding these mechanisms is key to developing antiviral strategies.
  • Further research is needed to fully unravel the complexities of autophagy manipulation by viruses.