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Updated: Feb 11, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility
Jamaji C Nwanaji-Enwerem1, Marc G Weisskopf2, Andrea A Baccarelli3
1Department of Environmental Health, Harvard T.H. Chan School of Public Health and MD-PhD Program, Harvard Medical School, Boston, MA, USA.
Abstract:
The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems.
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