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Updated: Feb 11, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Eye salvage in diffuse anterior retinoblastoma using systemic chemotherapy with periocular and intravitreal topotecan
Raksha Rao1, Santosh G Honavar1, Kaustubh Mulay2
1Ocular Oncology Service, Hyderabad, Telangana, India.
Abstract:
Diffuse anterior retinoblastoma is an infrequent presentation in which the tumor is confined to the anterior segment, and there is no retinal mass. An 18-month-old Asian Indian boy presented with white spots in the left eye. There were extensive anterior segment seeds without a retinal tumor. Fine-needle aspiration biopsy confirmed the diagnosis of retinoblastoma, and the patient received intravenous chemotherapy with a combination of vincristine-carboplatin-etoposide, periocular topotecan, and intravitreal topotecan to achieve complete tumor regression.
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