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Updated: Feb 11, 2026

Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
Intravenous immunoglobulin therapy for aspirin-heparinoid-resistant antiphospholipid syndrome
Shigeki Shimada1,2, Hideto Yamada3, Tatsuya Atsumi4
1Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine Sapporo Japan.
Abstract:
We encountered a woman who had a history of repeated fetal losses and positive tests for lupus anticoagulant, phosphatidylserine-dependent antiprothrombin (aPS/PT) IgG, IgM and kininogen-dependent antiphosphatidylethanolamine (aPE) IgG, IgM. Her previous pregnancy had ended in intrauterine fetal death at 24 weeks of gestation despite a therapy of low-dose aspirin, prednisolone and danaparoid. During the present pregnancy, she was treated with repeated intravenous infusions of immunoglobulin (IVIg) together with low-dose aspirin, prednisolone and heparin. When thrombocytopenia developed, she delivered a female baby weighing 2,152 g at 34 weeks of gestation by cesarean section. Titers of aPS/PT IgM and aPE IgM were reduced or maintained at low levels by repeated IVIg therapies. The IVIg therapy might be effective for aspirin-heparinoid-resistant antiphospholipid syndrome.
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