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Continuous subcutaneous lisuride infusions in Parkinson's disease.
P H Critchley1, F Grandas Perez, N P Quinn
1University Department of Neurology, Institute of Psychiatry, London, U.K.
Journal of Neural Transmission. Supplementum
|January 1, 1988
Summary
Continuous lisuride infusions improved motor function in Parkinson's disease patients with on-off fluctuations. However, frequent adverse effects limited long-term treatment success for most participants.
Area of Science:
- Neurology
- Pharmacology
Background:
- Idiopathic Parkinson's disease is characterized by motor fluctuations.
- Oral levodopa combined with dopa decarboxylase inhibitors (DDI) can lead to "on-off" fluctuations.
Purpose of the Study:
- To evaluate the efficacy and tolerability of continuous subcutaneous lisuride infusions for managing "on-off" fluctuations in Parkinson's disease.
Main Methods:
- Thirteen patients with idiopathic Parkinson's disease and "on-off" fluctuations were enrolled.
- Continuous 24-hour subcutaneous lisuride infusions were administered alongside a reduced dose of levodopa (plus DDI).
Main Results:
- Ten out of thirteen patients showed improved motor performance.
- A mean increase of 32% in "on" time was observed.
- Adverse effects, particularly psychiatric, were common, leading to withdrawal in 11 patients.
Conclusions:
- Continuous lisuride infusion is effective in improving "on-off" fluctuations in Parkinson's disease.
- High incidence of adverse effects restricts the successful application of this treatment technique.