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Updated: Feb 11, 2026

Reactive Vapor Deposition of Conjugated Polymer Films on Arbitrary Substrates
Published on: January 17, 2018
Synthetic polymers as substrates for a DNA-sliding clamp protein
S F M van Dongen1, J Clerx1, O I van den Boomen1
1Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
Abstract:
The clamp protein (gp45) of the DNA polymerase III of the bacteriophage T4 is known to bind to DNA and stay attached to it in order to facilitate the process of DNA copying by the polymerase. As part of a project aimed at developing new biomimetic data-encoding systems we have investigated the binding of gp45 to synthetic polymers, that is, rigid, helical polyisocyanopeptides. Molecular modelling studies suggest that the clamp protein may interact with the latter polymers. Experiments aimed at verifying these interactions are presented and discussed.
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