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Updated: Feb 11, 2026

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking
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Published on: August 29, 2018

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Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer

Elodie Henriet1,2, Margaux Sala1,2, Aya Abou Hammoud1,2

  • 1a INSERM, UMR1053, BaRITOn Bordeaux Research in Translational Oncology , Bordeaux , France.

Cell Adhesion & Migration
|April 28, 2018
PubMed

Insights

Discoidin domain receptors (DDR1 and DDR2) are collagen receptors increasingly linked to cancer. This review explores their roles in tumor growth, metastasis, and drug resistance, highlighting their potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Discoidin domain receptors (DDR1 and DDR2) are tyrosine kinase receptors that bind to collagen.
  • While not as extensively studied as integrins, DDRs are implicated in various cellular functions.
  • Recent research highlights their significant involvement in cancer progression.

Purpose of the Study:

  • To review the crucial roles of DDR1 and DDR2 in cancer hallmarks.
  • To summarize current understanding of DDR involvement in tumor proliferation, mutations, drug resistance, inflammation, angiogenesis, and metastasis.
  • To discuss the potential of DDRs as therapeutic targets in oncology.

Main Methods:

  • Literature review of studies investigating DDR1 and DDR2.
  • Analysis of DDR roles in cancer-related cellular processes and signaling pathways.
  • Synthesis of data on DDR involvement in tumor hallmarks.

Main Results:

  • DDRs are involved in cell cohesion, proliferation, adhesion, migration, and invasion.
  • DDRs play critical roles in tumor proliferation, cancer mutations, drug resistance, inflammation, neo-angiogenesis, and metastasis.
  • DDR signaling pathways are associated with multiple cancer-related functions.

Conclusions:

  • DDR1 and DDR2 are key players in multiple cancer hallmarks.
  • DDRs represent promising therapeutic targets for cancer treatment.
  • Further research into DDR inhibition strategies is warranted.
Keywords:
STED microscopyfenestraelivers sinusoidal endothelial cells (LSEC)

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