[Influential factors of cerebral oxygen saturation in 
pediatric cardiovascular surgery]

Area of Science:

• Pediatric Anesthesiology
• Neurocritical Care
• Cardiovascular Surgery

Background:

• Congenital heart disease (CHD) in children often requires complex surgical interventions.
• Anesthesia management during CHD surgery aims to maintain adequate cerebral oxygenation.
• Propofol is commonly used for anesthesia induction and maintenance.

Purpose of the Study:

• To identify intervention strategies for mitigating decreases in cerebral tissue oxygen saturation (SctO2) during anesthesia in pediatric CHD patients.
• To analyze factors influencing SctO2 during propofol-induced anesthesia.

Main Methods:

• Twenty-eight pediatric patients undergoing cardiac surgery were studied.
• Anesthesia was deepened using propofol (3 mg/kg) intravenous injection.
• Cerebral tissue oxygen saturation (SctO2), mean arterial pressure (MAP), heart rate (HR), bispectral index (BIS), blood gases (PaO2, PaCO2), hemoglobin (Hb), and middle cerebral artery mean flow velocity (MCA Vm) were monitored.

Main Results:

• SctO2 decreased by 4.99% after anesthesia induction (P>0.05).
• No significant changes were observed in MAP, PaO2, PaCO2, or Hb.
• Middle cerebral artery mean flow velocity (MCA Vm) significantly decreased post-anesthesia (P<0.05).
• Decreases in MAP, HR, PaCO2, and MCA Vm correlated positively with SctO2 reduction.

Conclusions:

• Reduced MAP, HR, PaCO2, and MCA Vm are risk factors for decreased SctO2 during anesthesia in pediatric CHD.
• Maintaining SctO2 stability is essential to prevent potential neurological complications in these high-risk patients.