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Updated: Feb 11, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
Skeletal Metastases and Benign Mimics on NaF PET/CT: A Pictorial Review
Emmanouil Panagiotidis1, Kimberly Lam2, Alpesh Mistry2
11 Department of Nuclear Medicine, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK.
Objective:
The aim of this article is to present examples in which sodium fluoride labelled with 18F (NaF) bone PET/CT would be a useful adjunct to guide complex clinical decisions about the staging, restaging, and treatment approach for patients with skeletal metastases and benign causes of NaF activity that can be mistaken for bone metastases. We present a pictorial review of selected cases of this cohort of patients.
Conclusion:
NaF PET/CT hybrid fusion imaging is extremely useful in identifying potential causes of pain in patients with malignancies that have an affinity for skeletal metastases. This technique can help detect bone metastases, in problem solving, and to direct appropriate management.
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