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Guidance Document: Global Pharmacoeconomic Model Adaption Strategies.

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Area of Science:

  • Health Economics
  • Pharmacoeconomics
  • Model Adaptation

Background:

  • Global pharmacoeconomic models require adaptation for local healthcare contexts.
  • Ensuring scientific integrity during model adaptation is crucial for decision-making.

Purpose of the Study:

  • To provide user-friendly recommendations and a checklist for adapting international pharmacoeconomic models.
  • To ensure local applicability of pharmacoeconomic models while maintaining scientific rigor.

Main Methods:

  • A working group of international experts convened to discuss model adaptation.
  • A systematic review of existing model adaptation studies was performed.
  • Stakeholder interviews were conducted to gather best practices for global adaptation.

Main Results:

  • A set of 16 recommendations for adapting pharmacoeconomic models was developed.
  • Recommendations cover cost and effectiveness estimation for local decision-making.
  • Guidance addresses ensuring the local acceptability of adapted models.

Conclusions:

  • The recommendations enhance the meaningfulness and credibility of pharmacoeconomic models for local stakeholders.
  • Improved consistency in pharmacoeconomic model adaptations is expected.
  • Guidance may encourage the design of more adaptable global models.