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Updated: Feb 11, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Insulin related lipodystrophic lesions and hypoglycemia: Double standards?
Sandro Gentile1, Felice Strollo2, Teresa Della Corte3
1Department of Internal Medicine, Campania University "Luigi Vanvitelli", Naples Italy; Coordinator of the Study Group on Injection Technique of AMD (Medical Association of Diabetology), Italy.
Abstract:
Lipohypertophy (LH) is the most common skin complication of incorrect injection technique which does not only represent an aesthetic defect but also severely disrupts insulin pharmacokinetics/pharmacodynamics. As a consequence of that, hormone release is delayed and unexplained/unpredictable hypoglycemia occurs, both deteriorating metabolic control while negatively affecting adherence to treatment and quality of life. The economic burden due to unwanted intra-LH injections is accounted for by inappropriately high insulin requirements, increased emergency-related hospitalizations, and loss of work days. Greater attention has to be paid by diabetes care teams to education programs with periodic refreshers to achieve better metabolic control and reduce the economic burden of diabetes.
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