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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Arterial thrombosis and cancer
Doron Aronson1, Benjamin Brenner2
1Department of Cardiology, Rambam Health Care Campus, Haifa, Israel; The Ruth & Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Thrombosis Research
|April 29, 2018
Summary
Cancer treatments can increase the risk of arterial thrombotic events (ATEs). Understanding the complex interplay of cancer, therapy, and cardiovascular factors is crucial for prevention and management.
Area of Science:
- Oncology
- Cardiovascular Medicine
- Hematology
Background:
- Cancer-associated arterial thrombotic events (ATEs) are a growing concern due to improved cancer survival and novel therapies.
- The risk of ATEs in cancer patients is multifactorial, involving traditional cardiovascular risk factors, malignancy type, and cancer treatments.
- Cancer treatments like chemotherapy, immunotherapy, and targeted therapies can induce endothelial injury and increase ATE risk.
Purpose of the Study:
- To summarize the complex pathobiology of cancer-associated ATEs.
- To highlight the role of specific malignancies and therapies in ATE development.
- To discuss strategies for the prevention and treatment of ATEs in cancer patients.
Main Methods:
- Review of current literature on cancer-associated arterial thrombotic events.
- Analysis of the multifactorial interactions contributing to ATE risk in cancer.
- Examination of the prothrombotic properties of cancer cells and therapy-related mechanisms.
Main Results:
- Cancer and its treatments significantly increase the risk of ATEs through complex mechanisms.
- Cancer cells possess prothrombotic properties, including platelet activation and altered coagulation/fibrinolysis.
- Specific therapies (chemotherapy, TKIs, VEGF inhibitors, radiotherapy) contribute to ATEs via endothelial injury.
Conclusions:
- Cancer-associated ATEs have a significant impact on patient prognosis.
- Improved awareness, risk factor optimization, and targeted antithrombotic strategies are essential for managing cancer-associated ATEs.
- Further research is needed to reduce the incidence of ATEs in cancer patients.
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