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Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
Published on: January 4, 2018
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Exosome-Mediated Pathogen Transmission by Arthropod Vectors
Michael Hackenberg1, Michail Kotsyfakis2
1Genetics Department & Biotechnology Institute, Biomedical Research Center (CIBM), University of Granada, Granada, Spain.
Trends in Parasitology
|April 29, 2018
Summary
Tick exosomes may play a key role in transmitting parasites between hosts. This review explores how these tiny vesicles could mediate interactions at the tick-host-pathogen interface.
Area of Science:
- Molecular biology
- Cell biology
- Parasitology
Background:
- Recent studies suggest tick exosomes are involved in parasite transmission.
- The cellular mechanisms at the tick-host-pathogen interface are not well understood.
Purpose of the Study:
- To summarize current hypotheses on the role of tick exosomes in parasite transmission.
- To explore the function of arthropod exosomes in the tripartite interaction between tick, host, and pathogen.
Main Methods:
- Literature review of molecular and cellular studies.
- Analysis of existing hypotheses regarding tick-host-pathogen interactions.
Main Results:
- Tick exosomes are proposed to be crucial mediators at the tick-host-pathogen interface.
- Arthropod exosomes may facilitate the transmission of pathogens by ticks.
Conclusions:
- Tick exosomes represent a significant area of research for understanding parasite transmission.
- Further investigation into the cellular events involving exosomes is warranted to elucidate their role in disease ecology.
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