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Complex regression Doppler optical coherence tomography.

Sahar Elahi1, Shi Gu1, Lars Thrane1

  • 1Case Western Reserve Univ., United States.

Journal of Biomedical Optics
|April 29, 2018
PubMed
Summary
This summary is machine-generated.

This study presents a new regression method for Doppler optical coherence tomography (OCT) that significantly improves accuracy and extends dynamic range for precise blood flow measurement in developing embryos.

Keywords:
Doppler optical coherence tomographyMHz Fourier domain mode locked laserhemodynamicshigh-speed optical coherence tomographyoptical coherence tomography

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Fluid Dynamics

Background:

  • Doppler optical coherence tomography (OCT) is crucial for non-invasive blood flow assessment.
  • Conventional Doppler OCT methods have limitations in accuracy and dynamic range, especially at low velocities or low signal-to-noise ratios.

Purpose of the Study:

  • To develop and validate a novel regression-based method to enhance Doppler OCT accuracy and extend its dynamic range.
  • To enable precise, real-time monitoring of blood flow dynamics in developing biological systems.

Main Methods:

  • Implemented a complex regression technique applied to high-density B-scans in polar coordinates, replacing the conventional two-point estimate.
  • Utilized a high-speed OCT system with a 1.68-MHz Fourier domain mode-locked laser for high-density B-scans (16,000 A-lines) at high frame rates (∼100 fps).

Main Results:

  • Reduced minimum detectable velocity from 12.25 mm/s to 374 μm/s, while maintaining accurate measurement of velocities up to 400 mm/s without phase wrapping.
  • Demonstrated superior accuracy and precision compared to conventional Doppler OCT, particularly under low signal-to-noise conditions.
  • Achieved extended dynamic range for monitoring embryonic blood flow across developmental stages without parameter adjustments.
  • Showcased recovery of hidden structural features using complex averaging.

Conclusions:

  • The novel complex regression method significantly enhances Doppler OCT performance, offering improved accuracy, precision, and an extended dynamic range.
  • This advancement facilitates more comprehensive and reliable assessment of microvascular dynamics, particularly in sensitive biological applications like embryonic development.