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Plaquing of Herpes Simplex Viruses
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Correlation between herpes zoster and stroke-A case-control study.
Hadiseh Hosamirudsari1, Parisa Rashed1, Farhad Afsari2
1Department of Infectious Diseases, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Journal of Medical Virology
|April 29, 2018
Summary
Herpes zoster (HZ) infection significantly increases stroke risk, particularly head zoster. Monitoring cerebrovascular disease is crucial for patients post-HZ, especially within the first month.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Cerebrovascular accident (stroke) is a leading global cause of death.
- Herpes zoster (HZ), commonly known as shingles, is increasingly recognized as a potential trigger for stroke.
- Stroke prevalence is high in Iran, necessitating research into associated risk factors like HZ.
Purpose of the Study:
- To investigate the correlation between Herpes zoster (HZ) infection and stroke.
- To assess the risk of stroke following HZ, with a focus on Asian populations.
- To determine if HZ is an independent risk factor for stroke.
Main Methods:
- A case-control study involving 105 stroke patients (cases) and 105 individuals without stroke history (controls).
- Participants aged 30-90 years were assessed for prior HZ infection.
- Logistic regression analysis was employed to evaluate the association between HZ and stroke, adjusting for age, sex, and hypertension.
Main Results:
- A significant difference in HZ infection rates was observed between stroke cases and controls (P < .0001).
- Head zoster, including ophthalmic zoster, was markedly higher in the stroke group (P < .0001).
- HZ was associated with a 5.84-fold increased risk of stroke (95% CI, 1.98-8.23), with the highest risk observed 2-4 weeks post-HZ onset. Ischemic strokes were more frequent than hemorrhagic strokes.
Conclusions:
- Herpes zoster infection, particularly head zoster, is significantly associated with an increased risk of stroke.
- Close monitoring for cerebrovascular diseases is recommended for patients with a history of head zoster, especially during the initial month following infection.
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