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Updated: Feb 11, 2026

Single Particle Cryo-Electron Microscopy: From Sample to Structure
Published on: May 29, 2021
Molecular basis of the skin barrier structures revealed by electron microscopy
Akemi Ishida-Yamamoto1, Satomi Igawa1, Mari Kishibe1
1Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Abstract:
The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesmosomes, tight junctions, cornified cell envelope and keratin filaments. In this review, we discuss the current knowledge of their ultrastructure, their molecular basis and their relevance to skin disease.
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