Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499
Ying Liu1, Lingxin Xiong2,3, Yan Zhou1
1Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
Background:
It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship.
Methods:
We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text. The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association.
Results:
159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected. In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant. Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model. Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model.
Conclusion:
Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility.
Insights
Single-nucleotide polymorphisms (SNPs) in microRNA-146a rs2910146 are linked to increased inflammatory bowel disease (IBD) susceptibility. Other microRNA SNPs studied showed no significant association with IBD risk.
Area of Science:
- Genetics
- Immunology
- Gastroenterology
Background:
- Single-nucleotide polymorphisms (SNPs) in microRNAs are implicated in inflammatory bowel diseases (IBDs).
- Limited retrospective research exists on the association between microRNA SNPs and IBD susceptibility.
- This meta-analysis aims to precisely estimate the relationship between specific microRNA SNPs and IBD risk.
Purpose of the Study:
- To investigate the association between microRNA gene polymorphisms and the hereditary susceptibility to inflammatory bowel diseases (IBDs).
- To provide a quantitative assessment of the relationship between selected microRNA SNPs and IBD development.
Main Methods:
- A systematic literature search was conducted in PubMed and Embase for studies on microRNA SNPs and IBD susceptibility.
- Eligible studies were selected based on abstract and full-text screening.
- A meta-analysis was performed using Stata 14.0, calculating odds ratios and 95% confidence intervals to assess association strength.
Main Results:
- Five eligible articles comprising nine case-control studies were included in the meta-analysis.
- The miRNA-196a2 rs11614913 polymorphism showed no significant association with IBD.
- miRNA-146a rs2910146 polymorphism was significantly associated with increased IBD susceptibility across multiple genetic models (allelic, homozygote, heterozygote, dominant).
- A positive relationship between miRNA-499 rs3746444 and IBD was observed in the homozygote model.
Conclusions:
- The miRNA-146a rs2910146 (G>C) polymorphism is associated with an increased susceptibility to inflammatory bowel disease.
- miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) polymorphisms did not demonstrate a clear association with IBD susceptibility in this meta-analysis.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:22MicroRNAs