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Updated: Feb 11, 2026
08:53
Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
Published on: October 2, 2017
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Carbohydrate binding through first- and second-sphere coordination within aromatic oligoamide metallofoldamers
Pedro Mateus1, Barbara Wicher, Yann Ferrand
1Université de Bordeaux, CNRS, Bordeaux Institut National Polytechnique, CBMN (UMR 5248), IECB, 2 rue Robert Escarpit, F-33600 Pessac, France. y.ferrand@cbmn.u-bordeaux.fr.
Chemical Communications (Cambridge, England)
|May 1, 2018
Summary
Aromatic oligoamide capsules bind metal ions, enabling them to recognize carbohydrate guests. Metal ions play a dual role in structure and guest recognition via coordination.
Area of Science:
- Supramolecular chemistry
- Chemical sensing
Background:
- Oligoamides are versatile building blocks for self-assembled structures.
- Metal-ion coordination is a common strategy for modulating molecular recognition.
Purpose of the Study:
- To investigate the carbohydrate recognition capabilities of metal-binding oligoamide capsules.
- To elucidate the role of metal ions in the capsule's structure and function.
Main Methods:
- Synthesis of aromatic oligoamide capsules.
- Metal ion binding studies.
- Circular dichroism (CD) and Nuclear Magnetic Resonance (NMR) titrations for guest recognition.
- X-ray crystallography for structural analysis.
Main Results:
- Aromatic oligoamide capsules demonstrated selective binding of carbohydrate guests in solution.
- CD and NMR titrations confirmed the interaction between capsules and carbohydrates.
- Crystallographic data revealed metal ions contribute to both capsule structure and carbohydrate recognition through direct or indirect coordination.
Conclusions:
- Metal-binding oligoamide capsules are effective platforms for carbohydrate recognition.
- Metal ions are crucial for capsule assembly and play an active role in the recognition process.
- This work provides insights into the design of metal-coordinated supramolecular hosts for sensing applications.
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