Helical Aromatic Oligoamide Macrocycle Incorporated with a Ferrocene Unit for Encapsulation and Chirality Signaling
Zejiang Liu1, Maoxia Yang1, Brice Kauffmann2
1College of Chemistry, Institute of Nuclear Science and Technology, Key Laboratory of Radiation Physics and Technology of Ministry of Education, Sichuan University, Chengdu 610064, China.
None:
A strategy for developing ferrocene-incorporated heteroditopic macrocycles for the recognition of zwitterionic proline is presented. The receptor features a well-defined helical cavity, and diastereomeric conformers result upon encapsulation of d/l-proline as indicated by X-ray crystallography. Incorporation of a ferrocene unit allows efficient chirality signaling, which is clearly manifested by circular dichroism and NMR spectroscopy upon guest binding. This work demonstrates a viable approach for constructing ditopic hydrogen-bonded aromatic oligoamide macrocycles capable of sensing zwitterionic amino acids.
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