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Updated: Feb 11, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Adjuvant therapy for advanced renal cell carcinoma
Matthew A Meissner1, Barrett Z McCormick1, Jose A Karam1
1a Department of Urology , The University of Texas MD Anderson Cancer Center , Houston , Texas , USA.
Expert Review of Anticancer Therapy
|May 1, 2018
Summary
Adjuvant systemic therapy is needed for high-risk renal cell carcinoma (RCC) after surgery. Current evidence is limited, necessitating further research into targeted and immune-based treatments for improved patient survival.
Area of Science:
- Oncology
- Nephrology
- Immunotherapy
Background:
- Locally advanced, non-metastatic renal cell carcinoma (RCC) conventionally treated with surgery has high recurrence rates and poor survival.
- There is a critical need for effective adjuvant systemic treatments to improve outcomes in these patients.
Purpose of the Study:
- To evaluate the current landscape and future directions of adjuvant systemic therapy for high-risk, non-metastatic renal cell carcinoma.
- To review patient selection strategies, immunotherapy, and targeted molecular agents in the adjuvant setting.
Main Methods:
- A comprehensive literature search was conducted using PubMed and ClinicalTrials.gov.
- Key topics reviewed include cytokine therapy, vaccine therapy, VEGF and non-VEGF targeted agents, and immune checkpoint inhibitors.
Main Results:
- Currently, strong evidence supporting the routine use of adjuvant therapy in high-risk RCC is lacking.
- Several targeted molecular therapies have been investigated, with only one currently approved for use in this setting.
Conclusions:
- Adjuvant therapy strategies for renal cell carcinoma require further development, with a need for genetic and molecular prognostic models to identify suitable candidates.
- Ongoing clinical trials investigating immunotherapy and targeted agents are crucial for establishing future adjuvant treatment paradigms.
Keywords:
Adjuvant therapycytokine therapyimmune checkpoint inhibitorsimmunotherapyrenal cell carcinomavaccine therapyMore Related Videos
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