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Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade
Chengpeng Wang1, Guangbin Dong1
1Department of Chemistry , University of Chicago , Chicago , Illinois 60637 , United States.
Abstract:
We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the need for strong acids or bases. Both cyclic and acyclic ketones, as well as α-branched aldehydes, are suitable substrates for coupling with secondary and tertiary alkyl bromides. Concise formal synthesis of Zanapezil is achieved using this β-alkylation method.
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