Related Experiment Video

Updated: Feb 11, 2026

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Unexplained reciprocal regulation of diabetes and lipoproteins

Sei Higuchi1,2, M Concepción Izquierdo1,2, Rebecca A Haeusler1,2

  • 1Columbia University College of Physicians & Surgeons, Naomi Berrie Diabetes Center.

Current Opinion in Lipidology
|May 1, 2018
PubMed
Abstract

Insights

Lowering LDL-cholesterol with statins may increase type 2 diabetes risk, while diabetes influences lipid metabolism. Research explores these complex interactions for better cardiovascular disease and diabetes management.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Syndrome

Background:

  • Type 2 diabetes is linked to dyslipidemia, increasing cardiovascular risk.
  • Statins, used to lower LDL-cholesterol, show an inverse relationship with diabetes risk.
  • Understanding these interactions is crucial for managing metabolic and cardiovascular health.

Purpose of the Study:

  • To review current findings on the relationship between type 2 diabetes and dyslipidemia.
  • To investigate the impact of antihyperglycemic medications on lipid profiles.
  • To explore the reciprocal effects of statins on diabetes risk and vice versa.

Main Methods:

  • Review of clinical trials and genetic evidence.
  • Analysis of genetic instruments, including single nucleotide polymorphisms and specific genes (HMGCR, NPC1L1, HNF4A, GCKR, APOE, PCKS9, TM6SF2, PNPLA3).
  • Examination of pharmacologic data on lipid-lowering and glucose-lowering therapies.

Main Results:

  • Multiple lines of evidence confirm an inverse relationship between LDL-cholesterol and diabetes.
  • Genetic and pharmacologic data suggest a similar inverse association for HDL-cholesterol.
  • Insulin resistance, rather than diabetes itself, may drive impaired VLDL-triglyceride metabolism; weight loss, bariatric surgery, and incretin therapies reduce triglycerides, while SGLT2 inhibitors may increase HDL- and LDL-cholesterol.

Conclusions:

  • Diabetes and lipoprotein metabolism are intricately interconnected.
  • Further research into glucose, fat, and cholesterol metabolism mechanisms is warranted.
  • These insights have significant implications for the treatment of type 2 diabetes and cardiovascular disease.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.5K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Concept Videos

Factors Influencing Attraction IV: Reciprocity01:28

Factors Influencing Attraction IV: Reciprocity

Reciprocity in attraction is fundamental to social and romantic relationships, shaping how individuals form and maintain connections. The psychological principle underlying this phenomenon is that people tend to like those who express liking toward them. Balance theory supports this tendency, suggesting that mutual attraction fosters psychological harmony, whereas one-sided affection leads to discomfort and cognitive dissonance.The Psychological Mechanisms Behind ReciprocityWhen individuals...
294
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.9K
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K