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Glycated hemoglobin targets and glycemic control: Link with lipid, uric acid and kidney profile

Anthony P Sunjaya1, Angela F Sunjaya1

  • 1Faculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No.1, Jakarta, Indonesia.

Diabetes & Metabolic Syndrome
|May 1, 2018
PubMed

Insights

Indonesian diabetic patients, regardless of glycemic control, show elevated lipid and kidney profiles, increasing cardiovascular and nephropathy risks. Enhanced monitoring is crucial for managing comorbidities and preventing complications.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Diabetes mellitus management requires monitoring of glycemic control and associated metabolic profiles.
  • Glycated hemoglobin (HbA1c) is a key indicator for assessing long-term glycemic control in diabetic patients.
  • Comorbidities like dyslipidemia, hypertension, and nephropathy are common in diabetic populations.

Purpose of the Study:

  • To compare uric acid, lipid, and kidney profiles in Indonesian diabetic patients with good versus poor glycemic control.
  • To analyze the management and complications associated with different glycemic control levels.
  • To evaluate risks for cardiovascular diseases and nephropathy based on glycemic control and metabolic parameters.

Main Methods:

  • Retrospective analysis of medical records from Hermina Podomoro General Hospital (January-December 2015).
  • Classification of diabetic patients into good and poor glycemic control groups based on HbA1c levels.
  • Comparison of biochemical parameters (urea, creatinine, uric acid, LDL, HDL) and comorbidities between the groups.

Main Results:

  • Fifty-five patients (29 good, 26 poor glycemic control) were analyzed; average age was 54 years.
  • Poor glycemic control group showed significantly worse glycemic parameters (p < 0.05).
  • No significant differences in urea, creatinine, uric acid, LDL, or HDL levels between groups (p > 0.05), though HDL was lower on average.
  • Common comorbidities included dyslipidemia, hypertension, and nephropathy.

Conclusions:

  • Diabetic patients, irrespective of glycemic control, often exceed optimal lipid and kidney profile targets.
  • Both good and poor glycemic control groups face similar elevated risks for cardiovascular diseases, nephropathy, and other diabetic complications.
  • Increased patient monitoring of lipid and kidney profiles is recommended to mitigate risks of comorbidities and long-term complications.
Abstract

Keywords:
Diabetes mellitusGlycemic controlKidney profileLipid profileUric acid

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