Related Experiment Video
Updated: Feb 11, 2026

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
Published on: January 3, 2016
Maximally informative next experiments for nonlinear models
Reginald L McGee1, Gregery T Buzzard2
1Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, United States.
Abstract:
Mathematical modeling is a powerful tool in systems biology; we focus here on improving the reliability of model predictions by reducing the uncertainty in model dynamics through experimental design. Model-based experimental design is a process by which experiments can be systematically chosen to reduce dynamic uncertainty in a given model. We discuss the Maximally Informative Next Experiment (MINE) method for group-wise selection of points in an experimental design and present a convergence result for MINE with nonlinear models. As an application, we illustrate the method on polynomial regression and an ODE model for immune system dynamics. The MINE criterion sequentially determines experiments that can be conducted to best refine model dynamics.
Related Concept Videos
Nonlinear Pharmacokinetics: Causes of Nonlinearity
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Application of Nonlinear Inequalities
Introduction to Nonlinear Inequalities
The Stanford Prison Experiment
Nonlinear Pharmacokinetics: Overview
Nonlinearity can arise due to the saturation of plasma protein-binding or...

