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Long non-coding RNAs: An essential emerging field in kidney pathogenesis.
Hakimeh Moghaddas Sani1, Mina Hejazian1, Seyed Mahdi Hosseinian Khatibi2
1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Summary
Long non-coding RNAs (lncRNAs) are key regulators in cellular functions and play significant roles in kidney diseases. Understanding lncRNA functions offers potential for new kidney disease therapeutics.
Area of Science:
- Genomics
- Molecular Biology
- Nephrology
Background:
- The human genome transcribes a majority into non-coding RNAs, including microRNAs and long non-coding RNAs (lncRNAs).
- LncRNAs are crucial regulators of gene expression and cellular pathways in homeostasis and development.
- Recent research highlights the significant involvement of lncRNAs in various kidney pathologies.
Purpose of the Study:
- To review the diverse roles and functions of lncRNAs in kidney pathogenesis.
- To highlight lncRNAs as essential regulators in renal disease.
- To explore the molecular mechanisms of lncRNAs in kidney pathophysiology.
Main Methods:
- Literature review of studies on lncRNAs and kidney diseases.
- Analysis of lncRNA involvement in specific renal conditions.
- Synthesis of current knowledge on lncRNA regulatory functions.
Main Results:
- LncRNAs are implicated in renal ischemia, injury, inflammation, and fibrosis.
- Their roles are recognized in glomerular diseases, renal transplantation, and renal cell carcinoma.
- LncRNAs act as novel and essential regulators in kidney pathogenesis.
Conclusions:
- LncRNAs are integral to understanding kidney disease mechanisms.
- Further insights into lncRNA functions can drive the development of novel therapeutics for kidney diseases.
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