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Updated: Feb 11, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted
Filippo Minutolo1, John A Katzenellenbogen1
1Department of Chemistry, University of Illinois, 600 S. Mathews Avenue, Box 37-5, Urbana, IL 61801 (USA), Fax: (+1) 217-333-7325.
Abstract:
A very stable heterogenized difunctional cyclopentadienyl-ring precursor, storable under ambient conditions, readily participates in the simultaneous formation of a η5 bond with a [fac-Re(CO)3 ]+ species and a σ bond with heteroatom (halides, carboxylates) or carbon nucleophiles (boronic acids) to produce halo-, acyloxy-, or carbon-substituted cyclopentadienyl-Re(CO)3 complexes in a one-pot reaction in yields of between 41 and 71 % [Eq. (1)]. No catalyst is required and unprotected (usually) sensitive functional groups are well tolerated.
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