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Updated: Feb 11, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Efficient Suzuki-Type Cross-Coupling of Enantiomerically Pure Cyclopropylboronic Acids
Shao-Man Zhou1, Min-Zhi Deng1, Li-Jun Xia2
1Laboratory of Organometallic Chemistry.
Abstract:
Optically active cyclopropanes (e.g. 1) can be prepared by the use of tartaric acid derivatives as chiral auxiliaries in the palladium-catalyzed cross-coupling of optically active cyclopropylboronic acids with electrophiles. The absolute configuration of the chiral carbon atom is retained, and the reaction proceeds with good yields and enantiomeric excesses. R=H, p-Ph, o-CO2 CH3 , p-CO2 CH3 , p-NO2 , o-OCH3 , m-OCH3 .
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