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Updated: Feb 11, 2026

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies
Published on: April 11, 2021
Desolvation of a Novel Microporous Hydrogen-Bonded Framework: Characterization by In Situ Single-Crystal and Powder
Cameron J Kepert1, Dusan Hesek1, Paul D Beer1
1Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QR (UK), Fax: (+44) 1865-272-690.
Abstract:
Despite significant structural rearrangement upon desolvation of a three-dimensional molecular framework of hexaaquacobalt cations and redox-active functionalized tetrathiafulvalene anions (see the picture; the area filled with water molecules is shown in gray), monocrystallinity and microporosity are retained. X-ray analyses show that a unique combination of hydrogen bonds and π⋅⋅⋅π interactions within the framework gives this material a structural flexibility not seen in zeolites or their analogues.
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