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Related Experiment Video

Updated: Feb 11, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Total Syntheses of Vancomycin.

Alex J Zhang1, Kevin Burgess1

  • 1Department of Chemistry, Texas A&M University, Box 30012, College Station, TX 77842-3012 (USA), Fax: (+1) 409-845-8839.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary

The total synthesis of vancomycin aglycon, a long-sought molecule, has been achieved by research teams led by Evans and Nicolaou. This summary highlights the similarities and differences in their groundbreaking synthetic strategies.

Keywords:
AntibioticsAtropisomerismNucleophilic aromatic substitutionsTotal synthesisVancomycin

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Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Medicinal Chemistry

Background:

  • The vancomycin aglycon is a complex natural product with significant therapeutic importance.
  • Its total synthesis has been a major challenge in organic chemistry for decades.
  • Achieving this synthesis is crucial for understanding structure-activity relationships and developing new antibiotics.

Purpose of the Study:

  • To report the first total synthesis of the vancomycin aglycon.
  • To compare and contrast the synthetic methodologies employed by different research groups.
  • To provide insights into the challenges and strategies for complex molecule synthesis.

Main Methods:

  • Utilized advanced synthetic organic chemistry techniques.
  • Employed multi-step reaction sequences.
  • Leveraged innovative strategies for constructing the complex molecular architecture.

Main Results:

  • Successful and simultaneous total synthesis of the vancomycin aglycon by two independent research groups (Evans and Nicolaou).
  • Detailed elucidation of the key steps and transformations in each synthetic route.
  • Identification of convergent and divergent strategies in the approaches.

Conclusions:

  • The total synthesis of vancomycin aglycon is now achievable, marking a significant milestone in synthetic chemistry.
  • The comparative analysis of the two syntheses offers valuable lessons for future complex molecule endeavors.
  • This achievement paves the way for further exploration of vancomycin derivatives and their therapeutic potential.