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Updated: Feb 11, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

A New Route to Heterosilsesquioxane Frameworks.

Frank J Feher¹, Daravong Soulivong¹, Frank Nguyen¹

¹Department of Chemistry, University of California at Irvine, Irvine, CA 92697 (USA), Fax: (+1) 714-824-2657.

Angewandte Chemie (International Ed. in English)

|May 2, 2018

Summary

Researchers created novel discrete heterosilsesquioxane frameworks by substituting oxygen atoms in a silicon-oxygen cage with various heteroatom groups. This method offers a straightforward pathway to diverse molecular structures.

Keywords:

Cage compounds Silicon

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Synthesis and Characterization of Functionalized Metal-organic Frameworks

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Published on: September 5, 2014

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Published on: March 8, 2024

Area of Science:

Inorganic Chemistry
Materials Science
Organosilicon Chemistry

Background:

Silsesquioxanes are a class of compounds with the general formula [RSiO_1.5]_n.
Discrete silsesquioxane frameworks, such as the cubic Cy₈ Si₈ O₁₂ structure, serve as versatile molecular building blocks.

Purpose of the Study:

To develop a facile synthetic route for discrete heterosilsesquioxane frameworks.
To explore the substitution of oxygen atoms within the silsesquioxane cage with heteroatom-containing groups (Z).

Main Methods:

Acid-catalyzed opening of the cyclohexyl-substituted octameric silicon-oxygen cage (Cy₈ Si₈ O₁₂) using triflic acid.
Treatment of the opened intermediate with various nucleophiles to introduce heteroatom functionalities (Z).

Main Results:

Successful synthesis of discrete heterosilsesquioxane frameworks by replacing oxygen atoms with diverse heteroatom groups (Z=NPh, SO₄, nBuBO₂, CrO₄).
Demonstration of a general method for functionalizing the silsesquioxane core.

Conclusions:

The substitution strategy provides a simple and effective route to novel discrete heterosilsesquioxane structures.
This approach expands the library of functionalized silsesquioxanes for potential applications in materials science and catalysis.