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Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants
Martin Kantlehner1, Dirk Finsinger1, Jörg Meyer2
1Institut für Organische Chemie und Biochemie der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching (Germany), Fax: (+49) 89-2891-3210.
Abstract:
Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.
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