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A Versatile Integrated Ambient Ionization Source Platform.

Wanpeng Ai1, Honggang Nie1, Shiyao Song1

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China.

Journal of the American Society for Mass Spectrometry
|May 2, 2018
PubMed
Summary
This summary is machine-generated.

A novel integrated ambient ionization source (iAmIS) platform combines multiple ionization techniques for efficient, versatile, and cost-effective high-throughput sample analysis from complex matrices.

Keywords:
Ambient sourceCombined ion sourceHigh-throughput screeningMechanism

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • High-throughput analysis of complex samples requires diverse ionization techniques.
  • Existing multi-ionization sources often lack versatility and efficiency.

Purpose of the Study:

  • To develop a versatile integrated ambient ionization source (iAmIS) platform.
  • To enhance efficiency, broaden applications, and reduce costs of ionization techniques.
  • To enable simultaneous detection of polar and nonpolar compounds.

Main Methods:

  • Integration of flowing atmospheric pressure afterglow (FAPA)/direct analysis in real time (DART), dielectric barrier discharge ionization (DBDI)/low-temperature plasma (LTP), desorption electrospray ionization (DESI), and laser desorption (LD).
  • Modulation of parameters to achieve individual and combined ionization modes.
  • Utilizing FAPA/DART&DESI for simultaneous polar and nonpolar compound detection via proton and charge transfer.

Main Results:

  • The iAmIS platform successfully integrates multiple ionization techniques.
  • Demonstrated simultaneous detection of polar and nonpolar compounds using FAPA/DART&DESI.
  • Enabled mass spectrometry imaging and surface-assisted laser desorption (SALDI) under ambient conditions.
  • Achieved flexibility in choosing ionization modes and broadened analyte detection scope.

Conclusions:

  • The iAmIS platform offers a flexible, efficient, and cost-effective solution for complex sample analysis.
  • It significantly broadens the scope of analyte detection compared to individual ion sources.
  • Facilitates advanced analytical applications like mass spectrometry imaging under ambient conditions.