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Ethical Issues in Research Involving Participants With Opioid Use Disorder
Emily Anderson1, Lindsay McNair2
11 Associate Professor, Neiswanger Institute for Bioethics, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Therapeutic Innovation & Regulatory Science
|May 2, 2018
Summary
Developing effective opioid addiction treatments requires addressing unique ethical challenges in research. This includes ensuring informed consent, avoiding undue inducement, and managing risks for participants in opioid use disorder studies.
Area of Science:
- Addiction Medicine
- Clinical Research Ethics
- Public Health
Background:
- The opioid use disorder epidemic necessitates effective treatment research.
- Research involving individuals with active addictions presents distinct ethical considerations.
Purpose of the Study:
- To outline and discuss the unique ethical challenges in conducting research with populations experiencing opioid use disorders.
- To inform sponsors, researchers, and IRBs about critical ethical issues in this research area.
Main Methods:
- Literature review and synthesis of current ethical thinking on research with vulnerable populations.
- Discussion of key ethical principles and their application to opioid addiction research.
Main Results:
- Key ethical issues identified include informed consent, decision-making capacity, and undue inducement.
- Challenges in ensuring voluntary participation and managing post-research risks like overdose are highlighted.
Conclusions:
- Researchers and IRBs must be vigilant in addressing the complex ethical landscape of opioid addiction research.
- Proactive ethical planning is crucial for protecting participants and advancing treatment development.
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