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Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
Published on: October 7, 2009
Moesin Involvement in Oral Carcinogenesis of the Lower Lip
Agnes Assao1, Paula Midori Yoshino1, Maria Carolina Malta Medeiros1
1Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
Background/Aim:
This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis.
Materials And Methods:
Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test.
Results:
The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates.
Conclusion:
Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma.
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