Related Experiment Video
Updated: Jan 8, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
Published on: April 25, 2025
Renal responses to atrial natriuretic factor in patients with congestive heart failure
R J Cody1, S A Atlas, J H Laragh
1Department of Medicine, New York Hospital-Cornell University Medical College, New York.
Abstract:
It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secreted in normal subjects and is increased in patients with congestive heart failure. Atrial natriuretic factor may be administered exogenously and the results of studies performed by our group indicate that natriuresis and diuresis are induced in normal subjects but not in patients with congestive heart failure. These findings, when taken together, suggest that ANF is increased in heart failure patients in response to the atrial distention associated with ventricular dysfunction and intrinsic renal insufficiency. The mechanism for the blunted renal response to atrial natriuretic factor in heart failure patients requires further clarification.
Related Concept Videos
05:12Murine Nasal Lavage Fluid Collection without Blood Contamination
03:40Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
04:35Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
08:47Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
06:49Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
07:15Intranasal Administration of CNS Therapeutics to Awake Mice

