Distal renal tubular acidosis in two children with acquired hypothyroidism

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Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
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Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

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Norma E Guerra-Hernández1, Karen V Ordaz-López1, Rosa Vargas-Poussou2

  • 1Servicio de Nefrología Pediátrica, Hospital General del Centro Médico Nacional «La Raza», Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, México.

Nefrologia
|May 3, 2018
PubMed

Insights

This study presents two pediatric cases of renal tubular acidosis (RTA) linked to autoimmune hypothyroidism. Findings highlight kidney complications and potential causes in these associated conditions.

Area of Science:

  • Pediatric Endocrinology
  • Nephrology
  • Autoimmune Diseases

Background:

  • Autoimmune hypothyroidism can present with complex complications.
  • Renal tubular acidosis (RTA) is a rare kidney disorder affecting children.
  • The association between autoimmune hypothyroidism and RTA requires further investigation.

Observation:

  • Two children diagnosed with autoimmune hypothyroidism also presented with RTA.
  • Case 1 experienced intestinal ileus, metabolic acidosis, and nephrocalcinosis.
  • Case 2 was diagnosed with RTA (type 3) two years after hypothyroidism diagnosis.

Findings:

  • Diagnosis of RTA in both cases was confirmed by decreased maximum urinary pCO2.
  • Case 2 demonstrated a proximal bicarbonate leak, indicative of type 3 RTA.
  • This represents the first reported cases of RTA associated with autoimmune hypothyroidism.

Implications:

  • The findings suggest a potential link between autoimmune hypothyroidism and RTA in children.
  • Kidney damage may result from thyroid hormone deficiency or autoantibodies.
  • Further research is needed to elucidate the mechanisms and clinical management.

Keywords:
Acidosis tubular renalAutoimmunityAutoinmunidadHipotiroidismoHypothyroidismMaximum urinary pCO(2)Renal tubular acidosispCO(2) urinaria máxima

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