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Hydrogen sulfide ameliorates aging-associated changes in the kidney
Hak Joo Lee1, Denis Feliers1, Jeffrey L Barnes1,2
1Department of Medicine, University of Texas Health San Antonio, 7703, Floyd Curl Drive, MC7882, San Antonio, TX, 78229, USA.
Geroscience
|May 3, 2018
Summary
Aging kidneys show reduced hydrogen sulfide (H2S) levels, contributing to fibrosis. Supplementing with H2S improved kidney function and reduced fibrosis markers in aging mice.
Area of Science:
- Gerontology
- Nephrology
- Biochemistry
Background:
- Aging kidneys undergo structural changes, including fibrosis.
- Hydrogen sulfide (H2S) shows potential in mitigating kidney fibrosis in disease models.
Purpose of the Study:
- To investigate the role of H2S in the aging kidney.
- To determine if H2S supplementation can ameliorate age-related kidney fibrosis and dysfunction.
Main Methods:
- Assessed H2S metabolism and related signaling pathways in young vs. old mice.
- Administered sodium hydrosulfide (NaHS) to aging mice for 5 months and evaluated kidney function and fibrosis markers.
Main Results:
- Old mice exhibited decreased H2S generation and AMPK activity, with increased fibrotic matrix proteins and activated insulin signaling.
- NaHS treatment in aging mice reduced fibrotic markers, glomerulosclerosis, and senescence-associated secretory phenotype components.
- NaHS administration improved glomerular filtration, indicated by reduced urinary albumin and serum cystatin C.
Conclusions:
- Aging-induced kidney changes are linked to H2S deficiency.
- H2S supplementation effectively ameliorates age-related kidney fibrosis and dysfunction by modulating key signaling pathways.
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