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Updated: Feb 11, 2026
12:17
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
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Mannosylated Constructs as a Platform for Cell-Specific Delivery of Bioactive Agents
1UKA Tarsadia University, Maliba Pharmacy College, Gopal-Vidyanagar Campus, Surat, Gujarat 394350, India.
Summary
Active drug targeting enhances drug concentration and selectivity using ligands. Mannose-functionalized constructs target cells expressing mannose receptors (MRs), improving drug and vaccine delivery.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Materials Science
Background:
- Drug targeting aims to improve therapeutic efficacy and reduce side effects by concentrating drugs at specific sites.
- Active targeting strategies utilize ligands that bind to receptors overexpressed on target cells, offering enhanced selectivity over passive methods.
- Mannose receptors (MRs) are key targets, particularly on antigen-presenting cells, due to their high affinity for mannose.
Purpose of the Study:
- To review the synthesis of mannosylated constructs for targeted drug delivery.
- To discuss the cellular uptake mechanisms of mannose-functionalized agents.
- To highlight the applications of mannose-targeted delivery systems for drugs and vaccines.
Main Methods:
- Review of literature on mannosylation techniques for drug carriers.
- Analysis of studies detailing mannose receptor-mediated cellular uptake pathways.
- Compilation of research on the application of mannosylated constructs in targeted therapy.
Main Results:
- Mannosylation is a versatile strategy for creating targeted drug delivery systems.
- Mannose receptor-mediated endocytosis is an efficient cellular uptake mechanism.
- Mannose-functionalized constructs show promise for targeted delivery of drugs, vaccines, and other bioactive agents.
Conclusions:
- Mannose-targeted delivery systems offer a promising approach for enhancing the efficacy and specificity of pharmaceuticals.
- The synthesis and application of mannosylated constructs warrant further investigation for advanced therapeutic strategies.
- Targeted delivery via mannose receptors can improve drug concentration at desired anatomical sites, particularly for immune cells.
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