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Updated: Feb 11, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Emerging therapies in psoriasis: a systematic review
Erica B Lee1, Mina Amin2, Tina Bhutani3
1John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, USA.
Cutis
|May 3, 2018
Summary
Emerging biologic therapies, including IL-17 and IL-23 inhibitors, show promising efficacy and safety for psoriasis treatment, potentially surpassing current options. Further long-term studies are needed to confirm these findings.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition with limited treatment options.
- New biologic therapies are under investigation to improve patient outcomes.
Purpose of the Study:
- To review and summarize findings on emerging biologic therapies for psoriasis.
- To evaluate the efficacy and safety of novel biologic agents in clinical trials.
Main Methods:
- Systematic review of published Phase 2 and 3 clinical trial data.
- Focus on IL-17 inhibitors (ixekizumab, brodalumab), IL-23 inhibitors (guselkumab, tildrakizumab, risankizumab), and TNF inhibitor (certolizumab pegol).
Main Results:
- Emerging biologics demonstrate promising clinical improvement in psoriasis symptoms.
- Safety profiles of these agents are generally favorable.
- Efficacy may be comparable or superior to existing psoriasis treatments.
Conclusions:
- Novel biologic agents, particularly IL-17 and IL-23 inhibitors, represent a promising advancement in psoriasis therapy.
- Long-term data are essential to fully establish the safety and efficacy of these emerging treatments.
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