Related Experiment Video
Updated: Feb 11, 2026

13:32
Modified Heterotopic Abdominal Heart Transplantation and a Novel Aortic Regurgitation Model in Rats
Published on: June 2, 2023
2.7K
Donor aortic dissection in a heart transplantation recipient
Matteo Pozzi1, Selina Hanna1, Laurent Sebbag2
1Department of Cardiac Surgery, "Louis Pradel" Cardiologic Hospital, Lyon, France.
Interactive Cardiovascular and Thoracic Surgery
|May 3, 2018
Summary
Aortic dissection, a rare complication following heart transplantation, can occur years later. This case highlights a Type A aortic dissection 16 years post-orthotopic heart transplant.
Area of Science:
- Cardiovascular Surgery
- Transplantation Medicine
- Aortic Disease
Background:
- Orthotopic heart transplantation (OHT) is a life-saving procedure for end-stage heart failure.
- Complications following OHT are well-documented, but aortic dissection remains exceptionally rare.
- Long-term surveillance and understanding of potential late complications are crucial in transplant recipients.
Observation:
- A patient developed a Type A aortic dissection 16 years after undergoing OHT.
- This delayed presentation of aortic dissection post-transplantation is unusual.
- The specific etiology and risk factors in this long-term post-transplant context require further investigation.
Findings:
- The case demonstrates that aortic dissection can manifest significantly late after OHT.
- Type A aortic dissection presents a critical surgical emergency, even in the context of prior transplantation.
- This report adds to the limited literature on aortic pathology in heart transplant recipients.
Implications:
- Clinicians should maintain a high index of suspicion for aortic pathology in long-term heart transplant survivors.
- Further research is needed to elucidate the mechanisms linking OHT and aortic dissection risk.
- Improved understanding may lead to enhanced screening protocols and management strategies for this unique patient population.
Related Concept Videos
Anatomy of the Heart
120.1K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
120.1K
Anatomy of the Heart
3.3K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
3.3K
Aortic Regurgitation I: Introduction
692
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
692
Overview of the Heart
14.1K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
14.1K
Conduction System of the Heart
13.6K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.6K
Tissue Transplantation
1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K

