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Cuscuta arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats
Ufuk Koca-Caliskan1, Ismet Yilmaz2, Asli Taslidere3
11 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University , Etiler-Ankara, Turkey .
Journal of Medicinal Food
|May 3, 2018
Summary
This study shows that Cuscuta arvensis (dodder) extracts protect the liver from damage and possess antioxidant properties. These findings support its traditional use in medicine.
Area of Science:
- Pharmacology
- Phytochemistry
- Toxicology
Background:
- Cuscuta arvensis (dodder) is a parasitic plant with traditional medicinal uses, particularly for liver ailments.
- Folk medicine in Turkey utilizes dodder for liver problems, knee pain, and neonatal hepatitis.
Purpose of the Study:
- To investigate the hepatoprotective and antioxidant effects of aqueous and methanolic extracts of Cuscuta arvensis.
- To evaluate these effects on acetaminophen (APAP)-induced acute hepatotoxicity in rats.
Main Methods:
- Administered aqueous and methanolic extracts of C. arvensis to rats with APAP-induced hepatotoxicity.
- Assessed liver function markers (enzymes, bilirubin, BUN) and oxidative stress indicators (SOD, MDA, GSH, catalase).
- Utilized chromatographic and spectroscopic methods for compound isolation and identification.
Main Results:
- Both aqueous and methanolic extracts demonstrated significant hepatoprotective and antioxidant effects.
- Reduced levels of liver enzymes, bilirubin, and BUN were observed.
- Improved antioxidant status, indicated by altered serum levels of SOD, MDA, GSH, and catalase.
- Kaempferol-3-O-rhamnoside was identified as a bioactive compound.
Conclusions:
- Cuscuta arvensis extracts possess notable hepatoprotective and antioxidant activities.
- These findings validate the traditional use of dodder for liver health.
- Kaempferol-3-O-rhamnoside is a key bioactive compound contributing to these effects.