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Myeloproliferative Neoplasms in Danish Twins
Michael Asger Andersen1, Ole Weis Bjerrum1, Ajenthen Ranjan1
1Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Acta Haematologica
|May 3, 2018
Summary
Myeloproliferative neoplasms (MPNs) show a 15% concordance in identical twins, suggesting a genetic role. This finding highlights the importance of genetic predisposition in MPN development.
Area of Science:
- Hematology
- Genetics
- Epidemiology
Background:
- Myeloproliferative neoplasms (MPNs) are clonal myeloid disorders.
- The role of genetic factors in MPN development is under investigation.
- MPN concordance in twin pairs is largely unknown.
Purpose of the Study:
- To investigate the concordance rate of MPNs in monozygotic and dizygotic twins.
- To assess the contribution of genetic predisposition to MPN development.
Main Methods:
- Utilized the Danish Twin Registry (1900-2010) and Danish National Patient Registry.
- Included twin pairs born between 1900-2010, with both twins alive from 1977 onwards.
- Analyzed 158 twin pairs diagnosed with MPNs (36 monozygotic, 104 dizygotic, 18 unknown zygosity).
Main Results:
- MPNs were diagnosed in both twins in 4 pairs.
- Probandwise concordance rate for monozygotic twins was 15%, compared to 0% for dizygotic twins (p=0.016).
Conclusions:
- A 15% concordance rate in monozygotic twins suggests a significant genetic predisposition for MPNs.
- Despite modest concordance, the findings are clinically relevant due to the rarity of MPNs.
- This study supports the role of genetic factors in the etiology of myeloproliferative neoplasms.
