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Ra223 in Bone Metastases with Osteolytic Activity.
Renato Patrizio Costa1, Davide Cardile1, Alessandra Murabito1
1Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy.
World Journal of Nuclear Medicine
|May 3, 2018
Summary
Radium 223 dichloride (Ra223), a targeted alpha therapy, showed potential in treating osteolytic breast cancer metastases. This finding expands therapeutic possibilities for Ra223 beyond prostate cancer.
Area of Science:
- Oncology
- Radiopharmaceuticals
- Medical Imaging
Background:
- Radium 223 dichloride (Ra223) is an approved targeted alpha therapy for prostate cancer with bone metastases.
- Current research primarily focuses on Ra223's efficacy in osteoblastic metastases.
- Osteolytic metastases represent a distinct bone pathology with different treatment considerations.
Observation:
- A breast cancer patient with osteolytic bone metastases received off-label Ra-223 treatment.
- Scintigraphy was used to identify regions of osteolysis prior to treatment.
- Positron emission tomography (PET) imaging evaluated the distribution of Ra-223 post-administration.
Findings:
- Ra-223 deposition demonstrated a precise overlap with the osteolytic regions identified by scintigraphy.
- This observation suggests Ra-223 may accumulate in and potentially treat osteolytic bone lesions.
- This is the first reported instance of Ra-223 deposition in osteolytic metastases.
Implications:
- These findings suggest a potential therapeutic role for Ra-223 in osteolytic bone metastases from various cancers.
- This opens new avenues for the development of Ra-223 as a treatment for a broader range of bone metastases.
- Further research is warranted to explore the efficacy and safety of Ra-223 in osteolytic bone metastases.
Keywords:
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