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Electrochemical detection of NGF using a reduced graphene oxide- titanium nitride nanocomposite
Zheng Wei1, Yanchun Wang2, Junping Zhang3
1Department of Oncology, Henan Academy Institute of Traditional Chinese Medicine, Zhengzhou, 450004, Henan, China.
Abstract:
There is a correlation between the severity of neurological impairment in patients that have suffered a cerebrovascular accident and the nerve growth factor (NGF) level. This study addressed the fabrication of a titanium nitride (TiN) and reduced graphene oxide (RGO)-based composite with remarkable electrocatalytic activity towards NGF oxidation in a phosphate buffer solution (PB, 0.1 M). The proposed electrochemical sensor was linearly related to the NGF concentration in the range of 10 nM-5 μM with a detection limit of 2.6 nM.
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