Emerging Systemic Therapies for Colorectal Cancer

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Orthotopic Mouse Model of Colorectal Cancer
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Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

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Christine M Veenstra1, John C Krauss1

  • 1Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Clinics in Colon and Rectal Surgery
|May 4, 2018
PubMed

Insights

Colorectal cancer (CRC) survival remains poor despite advances. This review covers current and emerging systemic therapies, including targeted agents and immunotherapy, to improve outcomes for advanced and metastatic CRC patients.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Colorectal cancer (CRC) remains a significant health concern with suboptimal survival rates, particularly for advanced and metastatic stages.
  • Despite 20 years of progress in screening, diagnosis, and treatment, 5-year survival for locally advanced CRC is 69%, dropping to 12% for metastatic disease.
  • There is a critical need for novel and effective systemic therapies to enhance long-term patient outcomes.

Purpose of the Study:

  • To review currently available systemic therapies for locally advanced and metastatic colorectal cancer.
  • To discuss emerging therapeutic strategies and recent advances in CRC treatment.
  • To highlight progress in identifying novel targeted agents and immunotherapeutic approaches for colorectal cancer.

Main Methods:

  • Literature review of current and emerging systemic therapies for colorectal cancer.
  • Analysis of survival data for locally advanced and metastatic colorectal cancer.
  • Synthesis of information on targeted agents and immunotherapies in colorectal cancer treatment.

Main Results:

  • Current systemic therapies offer limited long-term survival benefits for advanced and metastatic colorectal cancer.
  • Emerging targeted agents show promise in preclinical and clinical studies.
  • Immunotherapeutic agents have demonstrated exciting responses in a subset of colorectal cancer patients.

Conclusions:

  • Novel systemic therapies are essential to improve survival outcomes for colorectal cancer patients.
  • Targeted therapies and immunotherapies represent promising avenues for future colorectal cancer treatment.
  • Continued research into novel agents and treatment combinations is crucial for advancing colorectal cancer care.
Keywords:
clinical trialscolorectal canceremerging therapiesimmunotherapytargeted therapy

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