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Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs
Patricia N Vidal1,2,3, Diego D Miceli1,2,3, Elber Soler Arias1
1Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, Argentina.
Open Veterinary Journal
|May 4, 2018
Summary
Pituitary dependent hyperadrenocorticism in dogs lowers nitric oxide (NO) levels, leading to hypertension and potential kidney damage. Controlling diastolic pressure is crucial for managing renal health in affected dogs.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Nephrology
Background:
- Hyperadrenocorticism is a common canine disease.
- Excess cortisol causes severe adverse effects, including hypertension and renal damage.
Purpose of the Study:
- To investigate the relationship between nitric oxide (NO) levels, blood pressure, and renal function in dogs with pituitary dependent hyperadrenocorticism (PDH).
- To assess the impact of NO deficiency on hypertension and renal parameters in PDH dogs.
Main Methods:
- Studied 20 dogs with PDH and 12 controls.
- Measured cortisol, nitric oxide (NO), blood pressure, renal artery resistance index, glomerular filtration rate, and urine protein.
- Utilized Doppler ultrasound and radio-renogram excretion for assessments.
Main Results:
- Dogs with PDH had significantly lower NO levels compared to controls.
- Lower NO correlated with increased diastolic and systolic blood pressure.
- Hypertension, particularly diastolic, was prevalent (80%) and linked to increased urine protein and decreased glomerular filtration rate.
Conclusions:
- Decreased NO in PDH dogs contributes to hypertension.
- Diastolic blood pressure appears to significantly impact kidney damage in these dogs.
- Monitoring and controlling diastolic pressure is vital for preventing or managing renal complications in canine hyperadrenocorticism.
Keywords:
Blood pressionHyperadrenocorticism pituitary dependentNitric oxideRenal functionScintigraphyMore Related Videos
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