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Nickel chloride protection against alloxan- and streptozotocin-induced diabetes

E L Novelli¹, N L Rodrigues, B O Ribas

¹Departamento de Bioquímica, Universidade Estadual de São Paulo, Botucatu, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas

|January 1, 1988

Abstract:

The ability of NiCl2 to prevent alloxan- and streptozotocin-induced hyperglycemia was tested in rats. NiCl2 injected before alloxan and streptozotocin prevented the hyperglycemic response to the drugs. The protective effect of NiCl2 was linked to an increase in the specific activity of Cu-Zn superoxide dismutase (SOD). The effect of NiCl2 on SOD activity might be related to the effect of nickel on calcium, copper and zinc concentrations.

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